|
MEGLATHERY MD: RCCX THEORY:CYP21A2 Mutations May be Genetic Diathesis in the Stress-Diathesis Model For Psychiatric and Medical illness. Co-Segregating C4, CYP21A2, TNXB mutations May Explain Co-Occurrence of EDS/hypermobility, CFS/ME/FM, MCAS, POTS/OI/dysautonomia, Autism/Schizophrenia/Mood Disorders/Anxiety, etc. in Patients and Families. |
Sharon Meglathery MD: Thank you for considering distributing this information to researchers, scientists, clinical experts. I suggest that you print out the Summary (provides an introduction and is easy to follow), both pathophysiology diagrams. I think that anyone who grasps the main idea will recognize the importance of this discovery/theory.
| Pathophysiology I.pdf |
| Pathophysiology2: Self Perpetuation.pdf |
| Summary For Scientists July 2016.docx |
Pertains to:
- Ehlers-Danlos Syndrome, Hypermobility Type (EDS-HT)
- Chronic fatigue Syndrome (CFS)/Myalgic Encephalomyelitis (ME)
- Fibromyalgia (FM)
- Chronic Lyme Disease, Gulf War Syndrome, Toxic Mold/Biologic Illness
- Mast Cell Activation Syndrome (MCAS): histamine intolerance, migraines, diarrhea, sinus pain, burning eyes, syncope, distractibility, brain fog, irritability, interstitial cystitis, hyper-adrenergic POTS, etc., depending on location of the mast cells
- Postural Orthostatic Tachycardia (POTS)/Dysautonomia/Orthostatic Intolerance/Low Blood volume
- Pain Syndromes: Neuropathic Pain Syndromes/Chronic Regional Pain Syndrome/Myofascial Pain Disorder/Frequent Dislocations/Dysmenorrhea/Chronic Headache/Migraines/Interstitial Cystitis/Vulvodynia/Temporomandibular Joint Disorder (TMJ)
- GI Syndromes: Irritable Bowel Syndrome/Cyclical Vomiting/Gastroparesis/Food Intolerance/Gut dysbiosis/Candida overgrowth/Leaky Gut Syndromes, Malabsorption Syndromes
- Raised Intracranial Pressure Conditions: Pseudotumor Cerebri/Benign Intracranial Hypertension/Posterior Reversible Encephalopathy/Acquired Chiari Malformation
- Neurological Issues: Neuropathies/Pain Syndromes/Uncoordinated Swallow/Vertigo/Central Apnea/Sleep Paralysis/Dysautonomia/Seizure-Like Episodes/Dystonia/Narcolepsy
- Mitochondrial Disorders
- Immune Dysregulation: Combined Variable Immunodeficiency (CVID)/IgA deficiency/fungal infections/recurrent HSV infections/no colds for years, severe bacterial infections, inability to clear strep/Epstein Barr/mycoplasma/chlamydia/candida, dysbiosis, small intestinal bacterial overgrowth, multiple sclerosis (MS), autoimmune disorders-classic and non classic, i.e. mixed connective tissue disorders/eosinophilic disorders, high TGF beta/inflammatory conditions, Chronic Inflammatory Response Syndrome (CIRS)
- Psychiatric Issues: Psychiatric Conditions due to Dysautonomia (Panic/Anxiety)/ADD/Hyperfocus/Autistic Wiring/Sensory Processing Disorders/Psychosis/Schizophrenia/Chronic Illness: Stress and Loss/PTSD/Mood Disorders (Bipolar/Unipolar)/Chronic Insomnia/Restless Leg Syndrome/Brain Anatomic Abnormalities (big Amygdalae-fear and emotional center; small anterior cingulate; chiari malformation, hydrocephalus)
- Hormonal Disorders: sex hormone disorders-cystic ovaries, acne, water +/- fat associated weight gain, breast and tissue swelling, fertility issues, hot flashes/night sweats; adrenal gland issues: adrenal fatigue, Addison's, high/low cortisol, low aldosterone; pituitary hormone abnormalities-ACTH, TSH mediated thyroid disorders; autoimmune hormonal issues, etc...
- GU/Renal Issues: Fibromuscular Dysplasia, Diabetes Insipidus, Interstitial Cystitis
- Misc.: Extreme temperature dysregulation (dysautonomia or not), Multiple Chemical Sensitivity, High adrenaline/noradrenaline (also called norepinephrine) states, Erythromyalalgia, Raynaud's, Livedo Reticularis, Evidence of Poor connective tissue integrity (dislocations, bruising, bleeding, petechaie, etc), Dry eyes, Tinnitis
RCCX Project, Inc.: WWW.RCCXPROJECT.ORG
|
As a result of tremendous positive response to the RCCX Theory:
Karen Herbst MD PhD (Endocrinology) and I have set up a non-profit corporation to fund research investigating the possible role of the RCCX Module in familial chronic illness clusters (Ehlers-Danlos Hypermobility Type, Chronic Fatigue Syndrome, Fibromyalgia, Chronic Lyme, Mast Cell Activation Syndrome, Postural Orthostatic Tachycardia Syndrome, Pain Syndromes, Psychiatric Spectrum Disorder (including PTSD, Anxiety Disorders, Autism Spectrum Disorder, Bipolar Disorder, Psychosis, Depression, ADHD), Autoimmune/Immunological Disorders, Endocrine disorders,Subcutaneous Adipose Tissue Disorders and Neurological Conditions (Including raised Intracranial Pressure, Chiari, Chronic Migraine, etc.), etc.). We will be gathering a large amount of family and clinical data from people with chronic illness (CFS, chronic Lyme, FM, etc), hypermobility, the CAPS profile, CYP21A2 mutations and subcutaneous adipose tissue disorders and will compare with normal controls. We are trying to track down geneticists and other collaborators to assist us with phase 2. Should we have money left over, we will donate to the Open Medicine Foundation to assist Ron Davis PhD et al. in their pursuit of the cause and treatment of CFS/ME (which we are quite sure will eventually lead to the RCCX module). |
Please consider making a donation today. To our knowledge, no one else is looking at this!
We promise to spend your money wisely. We have no salaried employees. We are volunteering our time. We are both completely committed to finding answers. A heart-felt thank you for believing in us and helping us to try to crack this mystery!
RCCX Project, Inc.is a non-profit corporation formed April 12, 2016, based in Tucson, Arizona. It is organized exclusively for charitable or educational purposes within the meaning of section 501(c)(3) of the Internal Revenue Code.
We promise to spend your money wisely. We have no salaried employees. We are volunteering our time. We are both completely committed to finding answers. A heart-felt thank you for believing in us and helping us to try to crack this mystery!
RCCX Project, Inc.is a non-profit corporation formed April 12, 2016, based in Tucson, Arizona. It is organized exclusively for charitable or educational purposes within the meaning of section 501(c)(3) of the Internal Revenue Code.
For Credit Cards via Stripe:
For Paypal:
If you would like to send a check:
Please make it out to: RCCX Project, Inc.
Please mail to:
Karen Herbst, MD PhD
8987 East Tanque Verde Road, Suite #309-338
Tucson, Arizona 85749-9610
Please make it out to: RCCX Project, Inc.
Please mail to:
Karen Herbst, MD PhD
8987 East Tanque Verde Road, Suite #309-338
Tucson, Arizona 85749-9610
CONTACT INFORMATION:
Sharon Meglathery MD and Karen Herbst MD PhD.
Email: info@rccxandillness.com
FACEBOOK: RCCX and Chronic Illness
Offices: Sharon Meglathery MD, 1661 North Swan Road, Suite 102, Tucson, AZ 85712
Karen Herbst, MD PhD, 8987 East Tanque Verde Road, Suite #309-338, Tucson, Arizona 85749-9610
Website: www.RCCXProject.org
Sharon Meglathery MD and Karen Herbst MD PhD.
Email: info@rccxandillness.com
FACEBOOK: RCCX and Chronic Illness
Offices: Sharon Meglathery MD, 1661 North Swan Road, Suite 102, Tucson, AZ 85712
Karen Herbst, MD PhD, 8987 East Tanque Verde Road, Suite #309-338, Tucson, Arizona 85749-9610
Website: www.RCCXProject.org