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MEGLATHERY MD: RCCX THEORY:CYP21A2 Mutations May be Genetic Diathesis in the Stress-Diathesis Model For Psychiatric and Medical illness. Co-Segregating C4, CYP21A2, TNXB mutations May Explain Co-Occurrence of EDS/hypermobility, CFS/ME/FM, MCAS, POTS/OI/dysautonomia, Autism/Schizophrenia/Mood Disorders/Anxiety, etc. in Patients and Families. |
Sharon Meglathery MD: Thank you for considering distributing this information to researchers, scientists, clinical experts. I suggest that you print out the Summary (provides an introduction and is easy to follow), both pathophysiology diagrams. I think that anyone who grasps the main idea will recognize the importance of this discovery/theory.
| Pathophysiology I.pdf |
| Pathophysiology2: Self Perpetuation.pdf |
| Summary For Scientists July 2016.docx |
Pertains to:
- Ehlers-Danlos Syndrome, Hypermobility Type (EDS-HT)
- Chronic fatigue Syndrome (CFS)/Myalgic Encephalomyelitis (ME)
- Fibromyalgia (FM)
- Chronic Lyme Disease, Gulf War Syndrome, Toxic Mold/Biologic Illness
- Mast Cell Activation Syndrome (MCAS): histamine intolerance, migraines, diarrhea, sinus pain, burning eyes, syncope, distractibility, brain fog, irritability, interstitial cystitis, hyper-adrenergic POTS, etc., depending on location of the mast cells
- Postural Orthostatic Tachycardia (POTS)/Dysautonomia/Orthostatic Intolerance/Low Blood volume
- Pain Syndromes: Neuropathic Pain Syndromes/Chronic Regional Pain Syndrome/Myofascial Pain Disorder/Frequent Dislocations/Dysmenorrhea/Chronic Headache/Migraines/Interstitial Cystitis/Vulvodynia/Temporomandibular Joint Disorder (TMJ)
- GI Syndromes: Irritable Bowel Syndrome/Cyclical Vomiting/Gastroparesis/Food Intolerance/Gut dysbiosis/Candida overgrowth/Leaky Gut Syndromes, Malabsorption Syndromes
- Raised Intracranial Pressure Conditions: Pseudotumor Cerebri/Benign Intracranial Hypertension/Posterior Reversible Encephalopathy/Acquired Chiari Malformation
- Neurological Issues: Neuropathies/Pain Syndromes/Uncoordinated Swallow/Vertigo/Central Apnea/Sleep Paralysis/Dysautonomia/Seizure-Like Episodes/Dystonia/Narcolepsy
- Mitochondrial Disorders
- Immune Dysregulation: Combined Variable Immunodeficiency (CVID)/IgA deficiency/fungal infections/recurrent HSV infections/no colds for years, severe bacterial infections, inability to clear strep/Epstein Barr/mycoplasma/chlamydia/candida, dysbiosis, small intestinal bacterial overgrowth, multiple sclerosis (MS), autoimmune disorders-classic and non classic, i.e. mixed connective tissue disorders/eosinophilic disorders, high TGF beta/inflammatory conditions, Chronic Inflammatory Response Syndrome (CIRS)
- Psychiatric Issues: Psychiatric Conditions due to Dysautonomia (Panic/Anxiety)/ADD/Hyperfocus/Autistic Wiring/Sensory Processing Disorders/Psychosis/Schizophrenia/Chronic Illness: Stress and Loss/PTSD/Mood Disorders (Bipolar/Unipolar)/Chronic Insomnia/Restless Leg Syndrome/Brain Anatomic Abnormalities (big Amygdalae-fear and emotional center; small anterior cingulate; chiari malformation, hydrocephalus)
- Hormonal Disorders: sex hormone disorders-cystic ovaries, acne, water +/- fat associated weight gain, breast and tissue swelling, fertility issues, hot flashes/night sweats; adrenal gland issues: adrenal fatigue, Addison's, high/low cortisol, low aldosterone; pituitary hormone abnormalities-ACTH, TSH mediated thyroid disorders; autoimmune hormonal issues, etc...
- GU/Renal Issues: Fibromuscular Dysplasia, Diabetes Insipidus, Interstitial Cystitis
- Misc.: Extreme temperature dysregulation (dysautonomia or not), Multiple Chemical Sensitivity, High adrenaline/noradrenaline (also called norepinephrine) states, Erythromyalalgia, Raynaud's, Livedo Reticularis, Evidence of Poor connective tissue integrity (dislocations, bruising, bleeding, petechaie, etc), Dry eyes, Tinnitis
CONTACT INFORMATION:
Sharon Meglathery MD
Email: info@rccxandillness.com
FACEBOOK: Page: RCCX and Chronic Illness; Discussion Group: RCCX and Chronic Illness Discussion
Offices: Sharon Meglathery MD, 1661 North Swan Road, Suite 102, Tucson, AZ 85712
Sharon Meglathery MD
Email: info@rccxandillness.com
FACEBOOK: Page: RCCX and Chronic Illness; Discussion Group: RCCX and Chronic Illness Discussion
Offices: Sharon Meglathery MD, 1661 North Swan Road, Suite 102, Tucson, AZ 85712