Meglathery MD: Coinherited CYP21A2, TNXB, C4 Genes in Chronic illness (CFS, FM, Lyme, MCAS, POTS, Pain, Psychiatric Spectrum, Immunological, Endocrine) +- Hypermobility +- Autoimmune Diseases
  • Home
  • BACKGROUND
    • About Me
    • The RCCX module Explains Years of Clinical Observations
  • RCCX Theory: Chronic Illness
    • RCCX THEORY: Part I Genes and Properties of the RCCX Module Explain Clusters of Illness in Families and all the Symptoms/Syndromes Found in Chronic Illness
    • RCCX THEORY: Part II Connecting RCCX Theory to Mitochondrial Shutdown
    • Recap/Summary
    • Summary for Scientists
    • Downloads
    • Pathophysiology Diagrams
    • The No Longer Current Journal Article Introducing Early Version of the RCCX Theory, July 2015
  • RCCX Theory: Psychiatry
    • CYP21A2 Mutations May Be the Diathesis in the Stress-Diathesis Model for Chronic Medical and Mental Illness and May Cause a Psychiatric Spectrum, CAPS
  • New Developments

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​MEGLATHERY MD: RCCX THEORY:CYP21A2 Mutations May be Genetic Diathesis in the Stress-Diathesis Model For Psychiatric and Medical illness. Co-Segregating C4, CYP21A2, TNXB mutations May Explain Co-Occurrence of EDS/hypermobility, CFS/ME/FM, MCAS, POTS/OI/dysautonomia, Autism/Schizophrenia/Mood Disorders/Anxiety, etc. in Patients and Families.  

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​Sharon Meglathery MD:
Thank you for considering distributing this information to researchers, scientists, clinical experts.  I suggest that you print out the Summary (provides an introduction and is easy to follow), both pathophysiology diagrams. I think that anyone who grasps the main idea will recognize the importance of this discovery/theory.  

Pathophysiology I.pdf
File Size: 1636 kb
File Type: pdf
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meglathery-rccx_self_perpetuates.pdf
File Size: 76 kb
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Processes in Chronic Illness-link to Porges/Naviaux.pdf
File Size: 299 kb
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Summary For Scientists July 2016.docx
File Size: 28 kb
File Type: docx
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Pertains to: 
  • Ehlers-Danlos Syndrome, Hypermobility Type (EDS-HT)
  • Chronic fatigue Syndrome (CFS)/Myalgic Encephalomyelitis (ME)
  • Fibromyalgia (FM)
  • Chronic Lyme Disease, Gulf War Syndrome, Toxic Mold/Biologic Illness
  • Mast Cell Activation Syndrome (MCAS): histamine intolerance, migraines, diarrhea, sinus pain, burning eyes, syncope, distractibility, brain fog, irritability, interstitial cystitis, hyper-adrenergic POTS, etc., depending on location of the mast cells
  • Postural Orthostatic Tachycardia (POTS)/Dysautonomia/Orthostatic Intolerance/Low Blood volume
  • Pain Syndromes: Neuropathic Pain Syndromes/Chronic Regional Pain Syndrome/Myofascial Pain Disorder/Frequent Dislocations/Dysmenorrhea/Chronic Headache/Migraines/Interstitial Cystitis/Vulvodynia/Temporomandibular Joint Disorder (TMJ)
  • GI Syndromes: Irritable Bowel Syndrome/Cyclical Vomiting/Gastroparesis/Food Intolerance/Gut dysbiosis/Candida overgrowth/Leaky Gut Syndromes, Malabsorption Syndromes
  • Raised Intracranial Pressure Conditions: Pseudotumor Cerebri/Benign Intracranial Hypertension/Posterior Reversible Encephalopathy/Acquired Chiari Malformation
  • Neurological Issues: Neuropathies/Pain Syndromes/Uncoordinated Swallow/Vertigo/Central Apnea/Sleep Paralysis/Dysautonomia/Seizure-Like Episodes/Dystonia/Narcolepsy
  • Mitochondrial Disorders
  • Immune Dysregulation: Combined Variable Immunodeficiency (CVID)/IgA deficiency/fungal infections/recurrent HSV infections/no colds for years, severe bacterial infections, inability to clear strep/Epstein Barr/mycoplasma/chlamydia/candida, dysbiosis, small intestinal bacterial overgrowth, multiple sclerosis (MS), autoimmune disorders-classic and non classic, i.e. mixed connective tissue disorders/eosinophilic disorders, high TGF beta/inflammatory conditions, Chronic Inflammatory Response Syndrome (CIRS)
  • Psychiatric Issues: Psychiatric Conditions due to Dysautonomia (Panic/Anxiety)/ADD/Hyperfocus/Autistic Wiring/Sensory Processing Disorders/Psychosis/Schizophrenia/Chronic Illness: Stress and Loss/PTSD/Mood Disorders (Bipolar/Unipolar)/Chronic Insomnia/Restless Leg Syndrome/Brain Anatomic Abnormalities (big Amygdalae-fear and emotional center; small anterior cingulate; chiari malformation, hydrocephalus)
  • Hormonal Disorders: sex hormone disorders-cystic ovaries, acne, water +/- fat associated weight gain, breast and tissue swelling, fertility issues, hot flashes/night sweats; adrenal gland issues: adrenal fatigue, Addison's, high/low cortisol, low aldosterone; pituitary hormone abnormalities-ACTH, TSH mediated thyroid disorders; autoimmune hormonal issues, etc...  
  • GU/Renal Issues: Fibromuscular Dysplasia, Diabetes Insipidus, Interstitial Cystitis
  • Misc.: Extreme temperature dysregulation (dysautonomia or not), Multiple Chemical Sensitivity, High adrenaline/noradrenaline (also called norepinephrine) states, Erythromyalalgia, Raynaud's, Livedo Reticularis, Evidence of Poor connective tissue integrity (dislocations, bruising, bleeding, petechaie, etc), Dry eyes, Tinnitis 
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CONTACT INFORMATION:
Sharon Meglathery MD 

Email: [email protected]
FACEBOOK: Page: RCCX and Chronic Illness;  Discussion Group: RCCX and Chronic Illness Discussion
Offices:​  Sharon Meglathery MD, 1661 North Swan Road, Suite 102, Tucson, AZ 85712
               
Follow @RCCXTheory_MD
© COPYRIGHT 2015. ALL RIGHTS RESERVED.
  • Home
  • BACKGROUND
    • About Me
    • The RCCX module Explains Years of Clinical Observations
  • RCCX Theory: Chronic Illness
    • RCCX THEORY: Part I Genes and Properties of the RCCX Module Explain Clusters of Illness in Families and all the Symptoms/Syndromes Found in Chronic Illness
    • RCCX THEORY: Part II Connecting RCCX Theory to Mitochondrial Shutdown
    • Recap/Summary
    • Summary for Scientists
    • Downloads
    • Pathophysiology Diagrams
    • The No Longer Current Journal Article Introducing Early Version of the RCCX Theory, July 2015
  • RCCX Theory: Psychiatry
    • CYP21A2 Mutations May Be the Diathesis in the Stress-Diathesis Model for Chronic Medical and Mental Illness and May Cause a Psychiatric Spectrum, CAPS
  • New Developments